IIL Conducting Walk in interview on 11th February 2022 for Microbial Production & Engineering Departments at Hyderabad Plant.
About the Company : Indian Immunologicals Ltd (IIL) is the market leader in veterinary and human biologicals in India. It manufactures over 150+ products.
IIL operates one of the largest plants in the world for veterinary vaccines.
Brief History of IIL:
Indian Immunologicals was established by the National Dairy Development Board (NDDB) in 1982, as its unit, with the objective of making vaccines available to farmers at an affordable price. The unit was incorporated as Indian Immunologicals Limited in the year 1999.
IIL started manufacturing human vaccines in 1998 on a specific request by the Government of India. IIL is the second company in the world and first in India to launch purified vero cell rabies vaccine (PVRV) and markets it under the brand – Abhayrab.
Vaccine Production Jobs
Experience :- freshers to 05 years
Location: Gachibowli, Hyderabad
skills:- (Cell culture, Virus culture /Blending formulation)
Gender: Male
Qualification:- MSc / BSc (Biotechnology / Microbiology)
Engineering Jobs
Experience:- 6 to 8 yrs
Qualification:- Diploma(mech)
Domain: Pharma / Injectable.
Skills:- Auto cad, HVAC, Utilities, Breakdown Maintenance.
Application Process :
interested candidates can share your cv to my mail Id j.priyanka@indimmune.com
Walk in Interview on 11th February 2022 @10 am in our Gachibowli Plant
CURRICULAM VITAE V.S.RAMA CHANDRA MURTY Hyderabad, Alwal. PIN- 500010. Mobile No: +91- 9666198880. E-mail: chandu_biotech@rediffmail.com SUMMARY ➢ Post Graduate in Biotechnology with 21 years of experience in the manufacturing operations of biologics, vaccines and biological products process development, tech-transfer and commercial manufacturing. Background includes strong domain knowledge in upstream and purification. ➢ Technical expertise and niche products development strategy skills in the biologics, vaccines, and therapeutic vaccines from lab to commercial scale operations delivered the best results with challenging time lines. ➢ A keen planner with skills in conceptualization and effective process initiatives to enhance plant capacity, efficiency, and productivity. Well conversant with QMS & regulatory approach, industrial safety norms. FUTURE GOAL: • To establish my self in a leadership role and contribute my expertise for developing new vaccines, biologics. Educational Qualifications: M.Sc., Biotechnology from Andhra University campus 1st grade.Project “Production of monoclonal antibodies and applications.” Software Exposure: High-end technical project presentations preparation, SAP manufacturing integration and intelligence, e-QMS. Employment History: • Presently working as General Manager (GM) – Operations with Gland Pharma Ltd. Biotech division, Hyderabad-from 5th June 2021 to till date. • Deputy General Manager& Block Head – Viral vaccines bulk antigen manufacturing–Worked with Panacea biotech, Panjab-From Jully-2020 to May-2021. • Asst.General Manager –Operations and manufacturing technology from May-2013 to March-2020 Bharat biotech International ltd. Hyderabad. • Head of the Department (UPSTREAM) – Worked for Scigen Biopharma Ltd. Pune-From Sep-2010 to April 2013 • Manager-Production-Worked for Shasun Chemicals and drugs Ltd.Biotech Division-June 2008 to Aug2010 • Manager-Production-Worked for Dalas Biotech ltd., Haryana. From January 2007 to 2008 MAY • Senior Executive-Process development Department-Krebs Biochemical’s ltd., Andhrapradesh- Nov1998 to Jan 2007. FUNCTIONAL SKILL SET AND SELECTED CONTRIBUTIONS DURING EMPLOYMENT ➢ Present employer: Gland Pharma Ltd., as GM-Operations key functional responsibilities are Sputnik V tech-transfer from R&D lab to manufacturing, completion of Process validation batches and submission, execution of brownfield project for commercial manufacturing of vaccines. Installations and qualifications of single use bio reactor systems and process equipments. Direct the technical staff and QMS, documentation, engineering teams. COV2-Ad26 submission batches successfully completed.
➢ Previous employer: Panacea biotech as DGM-Operations (Block head) – Viral vaccines WHO pre qualified facility. • Responsible for manufacturing operations of WHO pre-qualified vaccines Hib PRP. • Scale up and commercial scale operations establishment of vaccines like Pneumococcal vaccine, dengue and Sputnik- COVID vaccine (For this vaccine worked at Panacea New Delhi- Research center as a project lead and established the Sputnik- Adino26 strain process) • Headed and worked with the production and cell culture team to run HEK cells culture with single use wave bags (50-200L), DBR- bioreactors CellBrX(0.5 L-50 L) and STR-stirred reactors. • Achievements: Full scale commercial operations for HIB, facility initiation and make it operational with all GMP requirements for COVID vaccine within the time frame.
➢ Previous employer Bharat Biotech international Ltd., • Responsible for the full Operational Management in handle and organize manufacturing facility. • Heading multiple functional rolls in the areas bio therapeutic bioprocess, process development (manufacturing technology- Pilot scale lab) for new vaccine molecules and commercial viral vaccine products. • Manage the Commercial production in the biologics division EGF-epidermal growth factor protein. • Direct the process development teams and accomplished new molecules process development for HPV, meningococcal, bio-therapeutic, plasmid DNA vaccine. • Accountable for all production functions therapeutics and vaccines (yield and quality) to ensure that sufficient product is manufactured at the appropriate level to meet supply chain requirements. • Determine staffing requirements, interview, hire and train new employees, goal setting,monitor and review the performance of team. • Manage manufacturing performance to meet corporate strategic and operation objectives through establishing, approving, and analyzing manufacturing activities. • Possess the Technical capability for trouble shooting on issues related to Vaccine development, cGMP manufacturing, and testing. DOCUMENTATION AND cGxP SKILLS: • Accomplished with good regulatory approaches and GDP requirements for process development, equivalency reports preparation for technology transfer, scale-up, and commercialization of new products. • Review QMS data and QRM-quality review management data for compliance,productivity, and goal achievement to determine areas needing operating cost reduction and process efficiency strategies improvement. • Establish and implement departmental policies, goals, objectives,and procedures, conferring with senior management, and team members. • Execution of projects new facility and up gradation (production capacity scale up) planning from URS preparations for equipments and facility modifications and technical finalization of equipment, facility layout as per the regulatory requirements with quality and cost-effective. • Review and author the SOPs, BMRs, Process validation (PV), cleaning validations (CV), media fill validations studies and PM schedules, implementation of QMS elements, oversee the handling of rejected materials and biohazardous waste material management. Selected Contributions • Published International patent: WO 2017/006349: Polysaccharide vaccine formulations and processes for industrial production of meningococcal polysaccharides. And generated drug substance for testing,
toxicology trails and formulations. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017006349 • Selected by the management as a facilitator and GMP monitor for the polio, ROTA vaccines facility during the WHO audits. • Administrated the HPV project initiation from regulatory approvals, clone importing, and pilot process setup within the timelines of project milestone. • EGF-therapeutic protein yield improved 15 gm to 35 gm. per batch by implementing innovative bioprocessmethods. Significant impact on increase of the product turnover and reduced operating cost. • Developed controlled trypsin protein digestion step in the purification, which has helped to increase the purity and shelf life and stability of the molecule. • Produced therapeutic protein HCG and DNA vaccine for human clinical trials phase I, collaborated with NII-Delhi and Prof.GP.Talwar. • Executed a large capEX project worth of aprox.5 crores for large-scale biological cream formulation manufacturing and filling facility. ➢ PREVIOUS EMPLOYER: Scigen Biopharma Pvt.Ltd.PUNE.(Currently known as MJ.biopharma) Worked for Insulin process development at R&D pilot lab and scale-up to commercial manufacturing (5KL). • As a core team member during the establishment of large scale insulin facility turn-key project expertise in the GMP facility designing,planning,commissioning, preparationand review and implementation of URS/FAT/SAT/IQ/OQ/PQ on various process equipments • Develop process understanding, perform gap analysis, FMEA, and generate process models and process flow diagrams. Lead investigator and SME for resolving manufacturing discrepancies. • Completed tech-transfer for Insulin product form pilot to large-scale 5000 lts.Followed by execution for commercial manufacturing operations. Selected Contributions • Lead the team of process, qualification and engineering team for the timely completion of the facility and equipments qualifications for the Insulin manufacturing plant. • Finalization of specifications based on process analytical technologies (PAT) and data-evaluation, in process limits for DS and DP at various stages of product life cycle. • Economize 30 % of the budget on process filtration cost. This has resulted good process cost optimization. ➢ PREVIOUS EMPLOYER: SHASUN CHEMICALS&DRUGS LTD, BIOTECH Division, CHENNAI. • Process development for recombinant microbial products streptokinase, GCSF facilitated fermentation technology transfer from pilot plant to production. • Planning and monitoring the fermentation and upstream purification process to achieve target yields & purity. Selected Contributions • Successfully executed the fermentation engineering trail batches, scale-up batches, and PV batches in line with the project time lines for the launch of first commercial recombinant product for the organization. • Successfully generated the toxicology trail material for GCSF in 10L fermenters and scale-up studies completed. ➢ PREVIOUS EMPLOYER: Dalas Biotech Limited (UK-BASED), HARYANA. • Production planning for the Enzyme Penicillin acylase fermentation with recombinant E.coli large scale fermenters (20 KL&5 KL) fermentation Process and purification.
• Optimizing the process kinetics and media optimization. Evaluation of process capability. • Daily/monthly reports preparation and reporting to senior management. Achievements • Executed efficient cleaning and sanitization procedures and training for the production employees to overcome contamination issue raised with the fermentation batches within a short frame of time. • Reduced the Fermentation Cycle from 34 hours to 24 hours by optimizing the % of inoculums and process parameters in 20 KL fermentation.
➢ PREVIOUS EMPLOYER: KREBSBiochemical’ s Limited, VISAKHAPATNAM (A.P) • Position: Senior Executive, Process development. • Core member in the Process development team for the fermentation processing for the antibiotics and APIs and enzyme products. Media optimizations and process kinetics scale up basing on the Shake flask Studies and Pilot Bio reactors data. Achievements • Adapted for the ascetic process operations in the lab and manufacturing areas, good documentation and cleaning procedures applied for manufacturing of products. Audits Experience: • During my professional tenure successfully led external audits like WHO, customer audits from various big biopharma companies, state and DCGI audits. • Trained and designated as qualified internal auditor for various products in the organization. Undertaking and managing regulatory inspections. Soft Skills: Ability to work simultaneously with multiple projects and effective communication with different teams adaptability to different organizational cultures, decision making based on the analytics of scientific data available and effective communication. Personal profile: Date of birth : 12THFebruary. Languages known : Telugu, Hindi and English, Tamil (Medium). Availability : Notice 1 month (negotiable) Declaration: I certify that all the above information is correct and hoping that my experience will be useful for your organization. Thanking you, V.S.RAMACHANDRA MURTHY. KEY SKILL SET: Technology transfer, process development for new biosimilars, cell culture and bacterial vaccines, scale-up of products, commercial manufacturing. Greenfield and brownfield projects execution and collaborations with technical partners. GLP and GMP facilities initiator and implementation along with team members.